Sharon Chinault Young, Ph.D.
Home town: Gaithersburg, MD
B.S. (Honors), Biology, The George Washington University
Ph.D. Molecular Cell Biology, Washington University, Advisor: Kendall J. Blumer
Dissertation: Molecular Mechanisms of G protein activation in Saccharomyces cerevisiae
Gates, A.C.*, Bernal-Mizrachi, C.*, Chinault, S.L.*, Feng, C., Schneider, J.G., Coleman, T., Malone, J.P., Townsend R.R., Chakravarthy, M.V., Semenkovich, C.F. Respiratory uncoupling in skeletal muscle delays death and diminishes age-related disease. Cell Metab. 6(6):497-505. *Co-first authors
Overton, M.C., Chinault, S.L., Blumer K.J. Oligomerization of G protein-coupled receptors: Lessons from the yeast Saccharomyces cerevisiae. Eukaryot Cell. 4(12):1963-70.
Chinault, S.L., Overton, M.C., Blumer, K.J. Subunits of a yeast oligomeric G protein-coupled receptor are activated independently by agonist but function in concert to activate G protein heterotrimers. J. Biol. Chem. 279(16): 16091-100.
Overton, M.C., Chinault, S.L., Blumer, K.J. Oligomerization, biogenesis and signaling is promoted by a glycophorin A-like dimerization motif in transmembrane domain 1 of a yeast G protein-coupled receptor. J. Biol. Chem. 278(49): 49369-77.
Chinault, S.L., Blumer K.J. The C-terminal tail preceding the CAAX box of a yeast G protein gamma subunit is dispensible for receptor-mediated G protein activation in vivo. J. Biol. Chem. 278(23): 20638-44.