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Building chemical probes based on the natural products YM-254890 and FR900359: Advances toward scalability

Synthesis

Uveal melanoma cells use ameboid and mesenchymal mechanisms of cell motility crossing the endothelium

Molecular Biology of the Cell

Targeting primary and metastatic uveal melanoma with a G protein inhibitor

Journal of Biological Chemistry

Chloroquine sensitizes GNAQ/11-mutated melanoma to MEK 1/2 inhibition

Clinical Cancer Research

Pharmacologic targeting of Gq reveals new pathways in uveal melanoma

Cancer Research

Macrophage secretion of miR-106b-5p causes renin-dependent hypertension

Nature Communications

Simulation of spontaneous g protein activation reveals a new intermediate driving GDP unbinding

Biophysical Journal

Targeting nucleotide exchange to inhibit constitutively active G protein a subunits in cancer cells

Science Signaling

Direct observation of GDP unbinding reveals multiple allosteric pathways underlie G-protein activation

Biophysical Journal

Proteolytic degradation of regulator of G protein signaling 2 facilitates temporal regulation of Gq/11 signaling and vascular contraction

Journal of Biological Chemistry

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